The Fox Chase Chemical Diversity Center, Inc. (FCCDC)

 

Selected Recent Publications

 

Loughran, H. M.; Han, Z.; Wrobel, J. E.; Decker, S. E.; Ruthel, G.; Freedman, B. D.; Harty, R. N.; Reitz, A. B. Quinoxaline-based inhibitors of Ebola and Marburg VP40 egress. Bioorg. Med. Chem. Lett. 2016, 26, 3429-3435.

Gregg, R. A.; Hicks, C.; Nayak, S. U.; Tallarida, C. S.; Nucero, P.; Smith, G. R.; Reitz, A. B.; Rawls, S. M. Synthetic cathinone MDPV downregulates glutamate transporter subtype 1 (GLT-1) and produces rewarding and locomotor-activating effects that are reduced by a GLT-1 activator. Neuropharmacology. 2016, in print (doi: 10.1016/j.neuropharm.2016.04.014. Epub 2016 Apr 13).

Emert-Sedlak, L. A.; Loughran, H. M.; Shi, H.; Kulp, J. L., III; Shu, S. T.; Zhao, J.; Day, B. W.; Wrobel, J. E.; Reitz, A. B.; Smithgall, T. E. Synthesis and evaluation of orally active small molecule HIV-1 Nef antagonists. Bioorg. Med. Chem. Lett. 2016, 26, 1480-1484.

Han, Z.; Madara, J. J.; Herbert, A.; Prugar, L. I.; Ruthel, G.; Lu, J.; Liu, Y.; Liu, W.; Liu, X.; Wrobel, J. E.; Reitz, A. B.; Dye, J. M.; Harty, R. N.; Freedman, B. D. Calcium Regulation of Hemorrhagic Fever Virus Budding: Mechanistic Implications for Host-Oriented Therapeutic Intervention. PLoS Pathog. 2015, 11 , e1005220.

Gregg, R. A.; Baumann, M. H.; Partilla, J. S.; Bonano, J. S.; Vouga, A.; Tallarida, C. S.; Velvadapu, V.; Smith, G. R.; Peet, M. M.; Reitz, A. B.; Negus, S. S.; Rawls, S. M. Stereochemistry of mephedrone neuropharmacology: enantiomer-specific behavioral and neurochemical effects in rats. Br. J. Pharmacol. 2015, 172(3), 883-894.

Martin, M. D.; Calcul, L.; Smith, C.; Jinwal, U. K.; Fontaine, S. N.; Darling, A.; Seeley, K.; Woitas, L.; Narayan, M.; Gestwicki, J. E.; Smith, G. R.; Reitz, A. B.; Baker, B. J.; Dickey, C. A. Synthesis, Stereochemical Analysis, and Derivatization of Myricanol Provide New Probes That Promote Autophagic Tau Clearance. ACS Chem. Biol 2015, 10, 1099-1109..

Vouga, A.; Gregg, R. A.; Haidery, M.; Ramnath, A.; Al-Hassani, H. K.; Tallarida, C. S.; Grizzanti, D.; Raffa, R. B.; Smith, G. R.; Reitz, A. B.; Rawls, S. M. Stereochemistry and neuropharmacology of a 'bath salt' cathinone: S-enantiomer of mephedrone reduces cocaine-induced reward and withdrawal in invertebrates. Neuropharmacology 2015, 91, 109-16.

Rubin, H.; Selwood, T.; Yano, T.; Weaver, D. G.; Loughran, H. M.; Costanzo, M. J.; Scott, R. W.; Wrobel, J. E.; Freeman, K. B.; Reitz, A. B. Acinetobacter baumannii OxPhos inhibitors as selective anti-infective agents. Bioorg. Med. Chem. Lett. 2015, 25, 378-383.

Pelletier, J. C.; Velvadapu, V.; McDonnell, M. E.; Wrobel, J. E.; Reitz, A. B. Intramolecular rearrangement of α-amino acid amide derivatives of 2-aminobenzothiazoles. Tetrahedron Lett. 2014, 55, 4193-4195.

Han, Z.; Lu, J.; Liu, Y.; Davis, B.; Lee, M. S.; Olson, M. A.; Ruthel, G.; Freedman, B. D.; Schnell, M. J.; Wrobel, J. E.; Reitz, A. B.; and Harty, R. N. Small Molecule Probes Targeting the Viral PPxY-Host Nedd4 Interface Block Egress of a Broad Range of RNA Viruses. Journal of Virology, 2014, 88, 7294-7306.

McDonnell, M. E.; Bian, H.;Wrobel, J.; Smith, G. R.; Liang, S.; Ma, H.; Reitz, A. B. Anilino-monoindolylmaleimides as potent and selective JAK3 inhibitors. Bioorg Med Chem Lett. 2014, 24, 1116-1121.

Caglic, D.; Krutein, M. C.; Bompiani, K. M.; Barlow, D. J.; Benomi, G.; Pelletier, J. C.; Reitz, A. B.; Lairson, L. L.; Houseknecht, K. L.; Smith, G. R.; Dickerson, T. J. Identification of clinically viable quinolinol inhibitors of botulinum neurotoxin A light chain. J. Med. Chem. 2014, 57, 669-676.

Smith, G. R.; Brenneman, D. E.; Zhang, Y.; Du, Y.; Reitz, A. B. Small-Molecule Anticonvulsant Agents with Potent In Vitro Neuroprotection and Favorable Drug-Like Properties. J. Mol. Neurosci. 2014, 52, 446-458.

Gregg, R. A.; Tallarida, C. S.; Reitz, A. B.; McCurdy, C.; Rawls, S. M. Mephedron (4-methylmethcathinone), a principal constituent of psychoactive bath salts, produces behavioral sensitization in rats. Drug Alcohol Depend. 2013, 133, 746-750.

Gregg, R. A.; Tallarida, C. S.; Reitz, A. B.; Rawls, S. M. Mephedrone interactions with cocaine: prior exposure to the ‘bath salt’ constituent enhances cocaine-induced locomotor activation in rats. Behavioural Pharmacology 2013, 24, 684-688.

Watterson, D. M.; Grum-Tokars, V. L.; Roy, S. M.; Schavocky, J. P.; Bradaric, B. D.; Bachstetter, A. D.; Xing, B.; Dimayuga, E.; Saeed, F.; Zhang, H.; Staniszewski, A.; Pelletier, J. C.; Minasov, G.; Anderson, W. F.; Arancio, O.; Van Eldick, L. J. Development of Novel In Vivo Chemical Probes to Address CNS Protein Kinase Involvement in Synaptic Dysfunction. PLoS ONE 2013, 8(6), e66226.

Ramoz, L.; Lodi, S.; Bhatt, P.; Reitz, A. B.; Tallarida, C.; Tallarida, R. J.; Raffa, R. B.; Rawls, S. M. Mephedrone ('Bath Salt') Pharmacology: Insights from Invertebrates, Neuroscience, 2012, 208, 79-84.

Lisek, R.; Yuvasheva, E.; Chiu, Y. T.; Reitz, A. B.; Liu-Chen, L. Y.; Rawls, S. M. Mephedrone (‘Bath Salt’) Elicits Conditioned Place Preference and Dopamine-Sensitive Locomotor-Sensitive Activation. Drug and Alcohol Dependence, 2012, 126, 257-262.

Cassel, J. A.; Ilyin, S.; McDonnell, M. E.; Reitz, A. B. Novel Inhibitors of Heat Shock Protein Hsp70-Mediated Luciferase Refolding that Bind to DnaJ, Bioorg. Med. Chem. Lett. 2012, 20, 3609-3614.

Cassel, J. A.; McDonnell, M. E.; Velvadapu, V.; Andrianov, V.; Reitz, A. B. The effects of small molecule inhibitors of nucleic acid binding to TDP-43 on TDP-43 metabolism and function. Biochimie, 2012, 94, 1974-1981.

Smith, G. R.; Caglič, D.; Čapek, P.; Zhang, Y.; Godbole, S.; Reitz, A. B.; Dickerson, T. J. Reexamining hydroxamate inhibitors of Botulinum neurotoxin serotype A: Extending towards the b-exosite. Bioorg. Med. Chem. Lett. 2012, 22, 3754-3757.

McDonnell, M. E.; Vera, M. D.; Blass, B. E.; Pelletier, J. C.; King, R. C.; Fernandez-Metzler, C.; Smith, G. R.; Wrobel, J.; Chen, S.; Reitz, A. B. Riluzole prodrugs for melanoma and ALS: design, synthesis, and in vitro metabolic profiling. 2012, Bioorg. Med. Chem., 20, 5642-5648.

Velvadapu, V., McDonnell, M. E., Jaffe, E. K., Reitz, A. B.  Facile Synthesis of Mutagen X (MX): 3-Chloro-4-(dichloromethyl)-5-hydroxy-5H-furan-2-one. Tetrahedron Letters, 2012, 53, 3144-3146.

Brenneman, D. E.; Smith, G. R.; Zhang, Y.; Du, Y.; Kondaveeti, S. K.; Zdilla, M. J.; Reitz, A. B.  Small-Molecule Anticonvulsant Agents with Potent in vitro Neuroprotection. J. Molecular Neuroscience, 2012, 47, 368-379.

Venkatesh, M., Wang, H., Cayer, J., Leroux, M., Salvail, D., Das, B., Wrobel, J., Mani, S. In Vivo and In Vitro Characterization of a Frist-in-Class Novel Azole Analog That Targets Pregnane X Receptor Activation. Molecular Pharmacology, 2011, 80, 124-135.

Čapek, P., Zhang, Y., Barlow, D.J., Houseknecht, K.L., Smith, G., Dickerson, T.J. Enhancing the Pharmacokinetic Properties of Botulinum Neurotoxin Serotype A Protease Inhibitors through Rational Design. ACS Chemical Neuroscience, 2011, 2, 288-293.

Reitz, A. B.; Ramirez, U. D.; Stith, L.; Du, Y.; Smith, G. R.; Jaffe, E. K. Pseudomonas aeruginosa Porphobilinogen Synthase Assembly State Regulators: Hit Discovery and Initial SAR Studies. ARKIVOC, 2010, 175-188.

Reitz, A. B.; Smith, G. R.; Tounge, B. A.; Reynolds, C. H. Hit Triage Using Efficiency Indices after Screening of Compound Libraries in Drug Discovery. Curr. Top. Med. Chem., 2009, 9, 1718-1724.